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Adipotide, a peptidomimetic with sequence CKGGRAKDC-GG-D(KLAKLAK)2, is an experimental proapoptotic drug that has been shown to cause rapid weight loss in mice and rhesus monkeys.
Adipotide’s mechanism of action is to target specific blood vessels supplying adipose tissue with blood, cause the vessels to shrink and the fat cells fed by those vessels to undergo apoptosis. Adipotide is designed to bind to two receptors, ANXA2 and prohibitin, that are specific to blood vessels supplying white adipose tissue.
Clinical studies reveal that adipotide is able to cause adipocytes apoptosis, which in turn causes reduction in mass, and volume and mass of the subcutaneous fat. The hormone causes a programmed cell death by depriving them nutrients and this cause cellular atrophy. Moreover in the mitochondrial cascade to increase the production of proteins from the amino acids while reducing fat cells.
Molecular weight: 2555.22
Peptide purity: > 99.0%.