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Assay: 99.46% by HPLC
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|Product name||Prilocaine hydrochloride|
|CAS No.||1786-81-8||Outer Packing||25kg/drum|
|Production date||2019.01.08||Shelf life||2021.01.07|
|Items of analysis||Specification||Results|
|Solubility||Freely soluble in water and in alcohol ，slightly soluble in chloroform，very slightly soluble in acetone; practically insoluble in ether||Complies|
|Identification||By IR absorption,To match with working standard||Complies|
|Should be positive response||Complies|
|Should display the reaction of chloride differentiated||Complies|
|Loss on drying||≤ 0.3%||0.13%|
|Residue on ignition||≤0.1%||0.03%|
|Residual solvents||Should be to match with the standard||Complies|
|Complies||99.0% ～101.0%（on the anhydrous basis)||99.46%|
Prilocaine hydrochloride is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Lö Fgren. In its injectable form, it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used forintravenous regional anaesthesia.
In some patients, a metabolite of prilocaine may cause the unusual side effect of methemoglobinemia, which may be treated with methylene blue.
Local anesthetic is a substance that causes loss of sensation only to the area to which it is applied without affecting consciousness. Most local anesthetics structures have amino-ester or an amino-amide group which are linked to hydrophilic (secondary or tertiary amine) and to hydrophobic group (aromatics) on the other side.