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Assay: 99.8% by HPLC
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Anastrozole is a non-steroidal drug which is used to treat breast cancer. Arimidex acts by suppressing the levels of estrogen in the body and thus reduces the growth of breast cancer. The drug is first line treatment in post menopausal women with early breast cancer or in those with advanced breast cancer despite taking tamoxifen. Arimidex is often combined with other drugs to treat breast cancer in post menopausal women. The drug has been used to treat early or advanced breast cancer in women all cultures and races.
|Production Bath||20190108||Production Date||2019-01-08|
|Specification||USP 32||Shelf life||2 Years|
|Result For Analysis|
|Description||White crystalline powder||Complies|
|Conform with standard IR
Conform with standard HPLC
|Solubility||Freely soluble in methanol,acetone,
ethanol and tetrahydrofuran.
And very soluble in acetonitrile
|Total Unspecified Impurity||Max. 0.2%||0.08%|
|Individual unspecified impurlty||Max. 0.1%||0.05%|
|Related compound B||Max. 0.2%||0.07%|
|Related compound C||Max. 0.2%||0.04%|
|Related compound D||Max. 0.1%||0.05%|
|Related compound E||Max. 0.1%||0.06%|
|Limit of cyclohexane||Max. 0.08%||ND|
|Limit of ethylacetate||Max. 0.1%||0.07%|
|Residue on ignition||Max. 0.1%||0.07%|
|Conclusion||This batch is complies with USP 32.|
Study data suggest dosages of 0.5 mg to 1 mg a day
1) Anastrozole is reducing men estrogens, including estradiol. Excess estradiol in men can cause benign prostatic hyperplasia, gynecomastia, and symptoms of hypogonadism.
2) Anastrozole can contribute to increased risk of stroke, heart attack, chronic inflammation, prostate enlargement
and prostate cancer. Some athletes and body builders use anastrozole as part of their steroid cycle
to reduce and prevent symptoms of excess estrogen–gynecomastia, emotional lability and water retention.
3) Anastrozole used off-label in children with precocious puberty, or children with pubertal gynecomastia. Following the onset of puberty, the epiphyseal plate begins to close due to an increased amount of estrogen production escaping local metabolism and spreading to the circulatory system. It is shown to help slow this process, and increase adult height prediction in adolescent males treated with protein-based peptide hormones for the treatment of growth hormone deficiency.
|Appearance||off-white color crystalline powder|
|Storage||Store in a cool, dry place, away from direct heat and light.|
|Melting Point||81.0 ~ 84.0℃|
|Usage||used to treat Breast cancer.|