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Assay: 99.08% by HPLC
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MK-677 (also known as ibutamoren mesylate), promotes the secretion of the growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1) (R, R).
MK-677 increases growth hormone levels, by mimicking the action of the hormone ghrelin (R), and binding to one of the ghrelin receptors (GHSR) in the brain (R). Activated GHSR stimulates growth hormone release from the brain.
GHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition (R). Therefore, we can expect that ibutamoren may also affect these functions. However, so far, clinical studies describe only the effects ibutamoren has on appetite – and as expected, like ghrelin, ibutamoren increases it.
A great thing about MK-677 is that it increases growth hormone levels with little or no increase in other hormones, such as cortisol (R, R). Cortisol suppresses the immune system, reduces wound healing, and impairs learning and memory, and it’s usually not good to have this hormone elevated.
|Characteristics||White to yellowish-white crystalline powder||conform|
|Melting point||32 ~ 37ºC||33~36ºC|
|Specific optical rotation||+77°~+82°||+79.3°|
|Loss on drying||≤0.5%||0.15%|
|Assay||97 ~ 103%||99.08%|
|Free heptanoic acid||≤0.2 %||0.10%|
|Residual solvents(GC)||Methanol ≤100ppm||Pass|
Results have been shown from doses between 5-25mgs a day, dose dependent results should be expected. Higher doses, over 50mgs, have been reported by some, but no need to overdo it.
1) Ibutamoren Helps Build Muscles
2) Ibutamoren Reduce Muscle Wasting
3) Ibutamoren Increases Bone Density
4) Ibutamoren Improves Sleep
5) Ibutamoren Combats Aging and May Increase Longevity
6) Ibutamoren May Have Nootropic Effects
7) Ibutamoren is Beneficial in Treating Growth Hormone Deficiency
8) Ibutamoren May Help with Wound Healing and Tissue Regeneration
9) Ibutamoren May Help with Hangovers
Alias: Ibutamoren mesylate, Nutrobal
Appearance: White crystalline powder
Storage: Store at -20° C
Dosage: between 5 to 25 milligrams daily in a 10-week cycle