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Assay: 99.81% by HPLC
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Avanafil acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina. Other similar drugs are sildenafil, tadalafil and vardenafil. The advantage of avanafil is that it has very fast onset of action compared with other PDE5 inhibitors. It is absorbed quickly, reaching a maximum concentration in about 30-45 minutes. About two-thirds of the participants were able to engage in sexual activity within 15 minutes.
|CAS No.||330784-47-9||Outer Packing||1KG/BAG|
|Production date||2019.01.02||Shelf life||2021.01.01|
|Items of analysis||Specification||Results|
|Appearance||white or off white crystalline powder||white crystalline powder|
|Solubility||soluble in dimethyl sulfoxide & slightly soluble in ethanol and methanol||complies|
|Identification (HPLC)||The principal peak in the chromatogram obtained with test solution is corresponds to retention time the principal peak in the chromatogram obtained with RS in the assay||complies|
|Loss on drying||not more than 0.5%||0.248%|
|Specific optical rotation||-18.0 °to -26.0°||-25.06°|
|Sulphated ash||not more than 0.1%||complies|
|Assay||98-102% on dry basis||99.81%|
Avanafil is used to treat erectile dysfunction, which is in a class of medications called phosphodiesterase inhibitors. It works by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. It does not cure erectile dysfunction or increase sexual desire, also does not preventPregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus.
Avanafil take by mouthas by tablet and it is usually taken with or without food, about 30 minutes before sexual activity.
Oral Avanafil is supplied as oval, pale yellow tablets containing 50 mg, 100 mg, or 200 mg debossed with dosage strengths. In addition to the active ingredient, avanafil each tablet contains fumaric acid and mannitol.