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Assay: 98%+ by HPLC
Capacity: 2mg/vial, 10mg/vial
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Gonadorelin (also called Gonadorelin Acetate) is a synthetically produced gonadotropin-releasing hormone (GnRH).
Gonadorelin primarily stimulates the synthesis and release of luteinizing hormone (LH) from the anterior pituitary gland. Follicle-stimulating hormone (FSH) production and release is also increased by gonadorelin, but to a lesser degree. In prepubertal females and some gonadal function disorders, the FSH response may be greater than the LH response.
Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function.
Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use.
|Other Name:||LH-RH, human, Gonadoreline, Gonadorelin Acetate|
|Cas No.||71447-49-9; 33515-09-2|
|Product Categories||Amino Acid Derivatives; Peptide; API;|
|Single Impurity (HPLC):||0.5%max|
|Amino Acid Composition:||±10% of theoretical|
|Peptide Content (N%):||≥80.0%|
|Water Content(Karl Fischer):||≤8.0%|
|Specific Rotation (20/D):||-55.0~-65.0°(c=1 1%HAc)|