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Oxytocin is a mammalian neurohypophysial hormone. Produced by the hypothalamus and stored and secreted by the posterior pituitary gland, oxytocin acts primarily as a neuromodulator in the brain. Oxytocin is released in large amounts after distension of the cervix and uterus during labor, facilitating birth, maternal bonding, and, after stimulation of the nipples, lactation. Both childbirth and milk ejection result from positive feedback mechanisms.
|Production Bath||20180108||Production Date||2018-01-08|
|Specification||USP 32||Shelf life||2 Years|
|Result For Analysis|
|Characteristic||White or almost white powder.||White powder|
|Retention time conforms to that of
the reference standard
|Amino acids||Asp: 0.90-1.10;Glu: 0.90-1.10
Pro: 0.90-1.10;Gly: 0.90-1.10
Leu: 0.90-1.10;Tyr: 0.7-1.05
Half-Cys: 1.4-2.1;Ile: 0.90-1.10
|Related substances (HPLC)||Impurity A≤1.5%||0.15%|
|Impurity C≤1.5%||Not Detected|
|Other single impurity≤0.5%||0.13%|
|Acetic acid (HPLC)||6.0%-10.0%||7.1%|
|Bacterial endotoxins||Less than 300 IU/mg||Conforms|
|AcN(GC)||Not more than 0.041%||Conforms|
|MeOH(GC)||Not more than 0.3%||Conforms|
|(GC)||Not more than 0.032%||Conforms|
Calculated with reference
to anhydrous,aceticacid free substance
|on powder||NLT 80.0 %||90.4%|
|NLT 480 IU/mg||542IU/mg|
|Conclusion||It complies with USP 32|
1) Oxytocin is used in veterinary medicine to facilitate birth and to stimulate milk release
2) Oxytocin analogues are used for labor induction and to support labor in case of difficult parturition. It has largely replaced ergometrine as the principal agent to increase uterine tone in acute postpartum hemorrhage.
Oxytocin intravenous drip, once the 2.5 – 5 units, with Sodium Chloride Injection diluted to each 1ml contains 0.01 units. Intravenous drip of the beginning of every minute of not more than 0.001 to 0.002 units, each 15 – 30 minutes increased 0.001 to 0.002 units, to achieve the contractions and normal childbirth is similar, the fastest per minute of not more than 0.02 units, usually 0.002 to 0.005 units per minute.
Control postpartum hemorrhage per minute intravenous drip of 0.02 – 0.04 units, expulsion of the placenta after intramuscular injection of 5 to 10 units.
Lactogenic just before a 2 – 3 minutes, with nasal drops a 3 drop, drop into one side or both sides of the nostril.
|Alias||Atonin, Endopituirina, Orasthin, Oxytocinum, Partocon, Pitocin, Piton, Pitupartin, Utedrin, Uteracon|
|Amino Acid Composition||±10% of theoretical|
|Peptide Content (N%)||>80.0%|
|Oxytocin Acetate Content||<12.0%|
|Storage||Closed 2 ~ 8ºC preservation|